Cattle: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle.
Sheep: For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, trematodes, lungworms, nasal bots and mites of sheep.

Dosage & Administration
Closamectin Injection should be administered at a dosage rate of 200 μg ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per 25 kg).
It should only be injected subcutaneously into the neck.
A maximum dose of 10ml should be administered at any one site with any residual volume administered at another site in the neck.
A sterile 16-gauge, one-inch needle is recommended. For the treatment and control of sheep scab an injection of Closamectin Injection for Sheep may be administered but must be followed with a second injection of an ivermectin only product seven days after the initial injection to treat clinical signs of scab and to eliminate mites. This injection should be administered at the other side of the neck.

Withdrawal Period 
Cattle: Meat and offal: 49 days.
Milk: Not authorised for use in cattle producing milk for human consumption including during the dry period.
Do not use during the last trimester of pregnancy in heifers which are intended to produce milk for human consumption

Sheep: Meat and offal: 28 days.
Milk: Not authorised for use in ewes producing milk for human consumption including during the dry period.
Do not use within 1 year prior to the first lambing in ewes intended to produce milk for human consumption.

Contraindictions, Warnings etc
Closamectin Injection is not for intravenous or intramuscular use. Avermectins may not be well tolerated in all non-target species (cases of intolerance with fatal outcome are reported in dogs – especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises). Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.

Please see below link to the Veterinary Medicines Product Information Database
http://www.vmd.defra.gov.uk/productinformationdatabase/Default.aspx