For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, lungworms, eyeworms, warbles, mites and lice of cattle. 

Dosage & Administration
The veterinary medicinal product should be administered topically at a dosage rate of 500 mg ivermectin per kg bodyweight and 20 mg closantel per kg bodyweight (1 mL per 10 kg).
The formulation should be applied along the midline of the back in a narrow strip between the withers and the tail head.
Assess bodyweight carefully prior to administration.
The timing for treatment should be based on epidemiological factors and should be customised for each individual farm. A dosing programme should be established by a veterinary professional.

Withdrawal Period
Cattle must not be treated within 28 days of slaughter for human consumption. 

Not authorised for use in cattle producing milk for human consumption including during the dry period. Do not use during the second half of pregnancy in heifers which are intended to produce milk for human consumption.

Due to the significant likelihood of cross-contamination of non-treated animals with this product due to grooming (licking), all animals in a group should be treated at the same time and treated animals should be kept separately from non-treated animals throughout the withdrawal period. Non-compliance with this recommendation may lead to residues violations in non-treated animals.

Contraindictions, Warnings etc
Closamectin Injection is not for intravenous or intramuscular use. Avermectins may not be well tolerated in all non-target species (cases of intolerance with fatal outcome are reported in dogs – especially Collies, Old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises). Do not use in cases of known hypersensitivity to the active substances or to any of the excipients. 

Please see below link to the Veterinary Medicines Product Information Database
http://www.vmd.defra.gov.uk/productinformationdatabase/Default.aspx